Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 1648 0.0 1.0 0.127 0.214
biological_process el 1648 0.0 1.0 0.598 0.268
biological_process ka 1648 0.0 1.0 0.121 0.213
biological_process rf 1648 0.0 1.0 0.127 0.214
cellular_component ct 184 0.0 0.905 0.17 0.253
cellular_component el 184 0.001 0.925 0.307 0.239
cellular_component ka 184 0.0 0.972 0.174 0.258
cellular_component rf 184 0.0 0.919 0.171 0.254
disease ct 1456 0.0 1.0 0.042 0.135
disease el 1456 0.0 1.0 0.167 0.224
disease ka 1456 0.0 1.0 0.042 0.138
disease rf 1456 0.0 1.0 0.042 0.135
genetic_interaction ct 1606 0.0 1.0 0.417 0.327
genetic_interaction el 1606 0.0 1.0 0.436 0.32
genetic_interaction ka 1606 0.0 1.0 0.84 0.364
genetic_interaction rf 1606 0.0 1.0 0.424 0.329
molecular_function ct 476 0.0 0.995 0.28 0.305
molecular_function el 476 0.0 0.998 0.404 0.285
molecular_function ka 476 0.0 1.0 0.277 0.307
molecular_function rf 476 0.0 0.995 0.28 0.305
pathway ct 555 0.001 1.0 0.274 0.342
pathway el 555 0.001 1.0 0.236 0.338
pathway ka 555 0.001 1.0 0.463 0.49
pathway rf 555 0.001 1.0 0.228 0.334
phenotype ct 1358 0.0 0.998 0.072 0.163
phenotype el 1358 0.0 0.998 0.253 0.195
phenotype ka 1358 0.0 1.0 0.07 0.169
phenotype rf 1358 0.0 0.998 0.072 0.164
protein_interaction ct 1657 0.0 1.0 0.07 0.163
protein_interaction el 1657 0.0 0.933 0.065 0.157
protein_interaction ka 1657 0.0 1.0 0.304 0.455
protein_interaction rf 1657 0.0 0.926 0.066 0.154

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 1676 0.0 1.0 0.141 0.241
integration_mean_by_presence el 1676 0.0 0.977 0.13 0.15
integration_mean_by_presence ka 1676 0.0 1.0 0.051 0.139
integration_mean_by_presence rf 1676 0.0 0.967 0.058 0.126
mean ct 1676 0.0 1.0 0.134 0.238
mean el 1676 0.0 0.975 0.119 0.141
mean ka 1676 0.0 1.0 0.042 0.13
mean rf 1676 0.0 0.939 0.052 0.118

CDF plots of non integrated kernels

CDF plots of integrated kernels